Alecensa 150 mg (224 tablets) Roche

Alecensa 150 mg (224 tablets) — Roche

Overview

Alecensa (Alectinib) is an innovative targeted therapy developed by Roche for the treatment of ALK-positive non-small cell lung cancer (NSCLC).
It works by blocking the abnormal ALK protein that drives cancer cell growth, helping to slow or stop tumor progression — including metastases to the brain.

Indications

Alecensa is indicated for:

• First-line treatment of ALK-positive locally advanced or metastatic NSCLC;
• Patients previously treated with crizotinib who experienced disease progression or intolerance;
• Adjuvant treatment following surgical tumor removal to reduce recurrence risk.

Mechanism of Action

Alectinib selectively inhibits the ALK tyrosine kinase, disrupting cell signaling pathways essential for tumor growth and survival.
It is effective against central nervous system metastases due to its ability to penetrate the blood-brain barrier.

Composition & Form

• Active ingredient: Alectinib hydrochloride
• Each capsule contains: 150 mg Alectinib
• Form: Oral capsules
• Package: 224 capsules (4 blisters × 56)
• Manufacturer: Roche / Chugai Pharmaceutical

Dosage & Administration

• Recommended dose: 600 mg twice daily with food.
• Swallow capsules whole — do not open or crush.
• Treatment continues until disease progression or unacceptable toxicity.
• Dose adjustment (450 mg twice daily) may be needed for patients with severe hepatic impairment.

Side Effects

Common:

• Fatigue, constipation, swelling, muscle pain;
• Elevated liver enzymes;
• Slow heart rate (bradycardia);
• Sunlight sensitivity.

Serious but rare:

• Hepatotoxicity;
• Interstitial lung disease or pneumonitis.

Contraindications

• Hypersensitivity to alectinib or any component of the formulation;
• Pregnancy and breastfeeding (consult a physician).

Warnings & Precautions

• Monitor liver function and heart rate regularly.
• Avoid direct sunlight — use protective clothing and sunscreen.
• Effective contraception is required during treatment and for at least 3 months after completion.

Storage

• Store below 30 °C, in original packaging, protected from light and moisture.
• Keep out of reach of children.