Allopurinol 100 mg 100 tablets

Allopurinol 100 mg, pack of 100 tablets.

Active Ingredient

Allopurinol — a xanthine oxidase inhibitor.

Dosage Form

Tablets 100 mg, packaging: 100 tablets.

Pharmacological Action / Mechanism of Action

Allopurinol reduces the production of uric acid in the body by inhibiting the enzyme xanthine oxidase, which catalyses the conversion of hypoxanthine → xanthine → uric acid.

By lowering uric acid levels in blood and urine, the risk of urate crystal deposition (for example in joints) and formation of kidney stones is reduced.

Indications

• Chronic gout and recurrent gouty attacks associated with elevated uric acid levels.
• Hyperuricemia associated with conditions such as chemotherapy, uric acid nephropathy, recurrent uric acid kidney stones.
• Prevention of uric acid kidney stones.

Contraindications

• Known hypersensitivity to allopurinol or any excipient.
• Acute gout attack (initiating therapy during an acute attack requires caution).
• Severe renal or hepatic impairment—dose adjustment or alternative therapy may be needed.

Dosage and Administration

• Dose should be determined by a physician based on individual factors (uric acid level, kidney function, etc.).
• Usually starting at 100 mg per day; may be increased (e.g., 200-300 mg or more) depending on response.
• Tablets taken orally, preferably with food and adequate fluids.
• If a dose is missed, take as soon as possible; do not double the next dose.

Side Effects

Common/moderate:

• Skin rash, itching.
• Diarrhea, nausea.

Serious:

• Severe skin reactions (e.g., Stevens-Johnson Syndrome, TEN).
• Liver or kidney dysfunction.

Storage

Store at room temperature in a dry place, away from light, and out of reach of children.

Important Notes

• Treatment may need to continue for months or longer to achieve optimal benefit.
• Adherence is crucial — do not stop medication without consulting your healthcare provider.
• Alcohol and high-purine foods may compromise treatment effectiveness.
• If you experience any serious reactions, especially skin rash or signs of allergic reaction — seek immediate medical attention.

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