Enzalutamide​ ​Indenza (40 mg / 160 mg) Xtandi

Manufacturer: Aprazer Healthcare Pvt. Ltd., India

Overview

Indenza contains Enzalutamide, a potent androgen receptor inhibitor used in the treatment of advanced and metastatic prostate cancer. It works by blocking the effect of male hormones (androgens) that stimulate the growth of prostate cancer cells.

This medicine is a trusted generic alternative to Xtandi, offering clinically proven efficacy at a more affordable cost.

Therapeutic Indications

Indenza (Enzalutamide) is prescribed for:

Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) — in combination therapy

Cases where cancer continues to progress despite androgen deprivation treatment

Mechanism of Action

Enzalutamide selectively binds to androgen receptors, preventing their activation and nuclear translocation. This process blocks androgen-driven gene expression and inhibits the growth of prostate cancer cells.

Unlike earlier antiandrogens, Indenza shows no agonistic activity at the receptor level, ensuring more consistent therapeutic outcomes.

Dosage and Administration

Recommended dose: 160 mg once daily (with or without food)

Administered orally with water at the same time each day

Treatment should be continued under the supervision of an oncologist

Dose adjustments may be required in patients taking strong CYP2C8 inhibitors or in those with hepatic impairment.

Available Forms

Indenza 40 mg — pack of 112 capsules

Indenza 160 mg — pack of 28 capsules

Possible Side Effects

Common side effects may include:

Fatigue, hot flashes, or sweating

High blood pressure

Back or joint pain

Mild dizziness or headache

Serious but rare side effects:

Seizures

Falls or fractures due to bone weakness

Hypersensitivity reactions

If any severe or unusual symptoms occur, discontinue the medication and contact a healthcare professional immediately.

Precautions

Not intended for use in women or children

Use with caution in patients with liver or kidney dysfunction

Avoid concurrent use with strong enzyme inducers/inhibitors without medical guidance

Storage

Store below 25°C, in a dry, dark place.

Keep out of reach of children.

Why Choose Indenza

Clinically proven bioequivalent to Xtandi®

Cost-effective and high-quality alternative from Aprazer Healthcare

Manufactured in GMP-certified facilities in India

Trusted by oncologists in multiple countries