Nafithromycin (Miqnaf®) 400 mg 6 tab

Nafithromycin (Miqnaf®) 400 mg 6 tab

Overview

Nafithromycin (brand name Miqnaf®) is a next-generation oral antibiotic developed by Wockhardt Ltd (India). It belongs to the lactone-ketolide class of antibiotics and is indicated for the treatment of community-acquired bacterial pneumonia (CABP) in adults.
This innovative agent provides broad-spectrum antibacterial activity, including efficacy against macrolide-resistant strains of respiratory pathogens.

Composition

• Active ingredient: Nafithromycin
• Strength per tablet: 400 mg
• Dosage form: Tablets
• Manufacturer: Wockhardt Ltd., India

Pharmacological Class

Lactone-ketolide antibiotic

Mechanism of Action

Nafithromycin works by binding to bacterial ribosomal RNA, inhibiting protein synthesis and preventing bacterial growth. It demonstrates potent activity against Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Mycoplasma pneumoniae, and Chlamydophila pneumoniae.

Indications

• Community-acquired bacterial pneumonia (CABP)
• Other bacterial respiratory infections (as directed by a physician)

Dosage and Administration

• Recommended daily dose: 800 mg (two 400 mg tablets taken once daily)
• Duration of therapy: 3 days
  Dosage may vary depending on the patient's condition and medical guidance.

Advantages

• Active against macrolide-resistant bacteria
• Short 3-day treatment course improves adherence
• Excellent tissue penetration in the lungs and macrophages
• Well-tolerated with a favorable safety profile
• Convenient once-daily oral dosing

Clinical Data

Phase III clinical studies have shown that Nafithromycin achieves a 96.7% clinical cure rate in patients with CABP — comparable to 7-day moxifloxacin therapy but with a shorter and better-tolerated regimen.

Storage

Store below 25°C in a dry place. Protect from light and moisture. Keep out of reach of children.

Precautions

• Use with caution in patients with severe hepatic impairment
• Contraindicated in patients with known hypersensitivity to macrolide or ketolide antibiotics
• Use only under medical supervision