Noxalk (Ceritinib) 150 mg 30 tab.

Noxalk 150 mg is an anti-cancer medication containing the active ingredient ceritinib, a tyrosine kinase inhibitor (ALK inhibitor). It is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a translocation or alteration in the anoplastic lymphoma kinase gene (ALK-positive).

Dosage and Packaging

Tablets (capsules) with a dosage of 150 mg. The package contains 30 tablets.

Mechanism of Action

Ceritinib blocks the activity of the ALK protein and may also affect IGF-1R, InsR, and ROS1, resulting in reduced proliferation of tumor cells dependent on ALK signaling.

Indications for Use

* Metastatic ALK-positive non-small cell lung cancer (NSCLC) in adult patients, particularly after failure of therapy with another ALK inhibitor, such as crizotinib.

Dosage and Administration

* The dosage should be determined by an oncologist based on the clinical presentation. The usual starting dose for ceritinib is 450 mg once daily with food.

* Taken at approximately the same time each day. Swallow the tablets whole; do not chew or break them.

* Duration of therapy: until disease progression or unacceptable toxicity.

Contraindications and Warnings

* Hypersensitivity to ceritinib or any of the excipients.

* Caution is required in patients with severe liver impairment.

* During therapy, monitor liver function, signs of pneumonitis/interstitial lung disease, and ECG parameters (QT prolongation).

* Women of childbearing age and men whose partners may become pregnant are advised to use reliable contraception during and for some time after treatment.

Side effects

Common:

* Diarrhea, nausea, vomiting, gastrointestinal disturbances.

* Increased liver enzymes.

* Fatigue, decreased appetite, headache.

Severe:

* Interstitial lung disease/pneumonitis (in some cases fatal).

* QT prolongation, bradycardia.

* Liver damage (including severe forms).

Storage conditions

Store in the original packaging, in a dry place, at the temperature specified in the package insert (usually up to 25°C). Keep out of reach of children and away from light.

Important Instructions

* This medication is available by prescription and should only be prescribed by an oncologist.

* It is not recommended to stop taking it or change the dosage on your own.

* Adherence to a diet, regular laboratory monitoring, and reporting any unusual symptoms to your doctor are mandatory.

* The genetic status of the tumor (presence of ALK transformation) must be confirmed before use.