Pirenoxine Ophthalmic Suspension 0.005% – Santen

Pirenoxine Ophthalmic Suspension 0.005% – Santen

• Active ingredient: Pirenoxine 0.005% (0.005 g per 100 mL)
• Dosage form: Ophthalmic suspension, 5 mL dropper bottle
• Manufacturer: Santen Pharmaceutical Co., Ltd., Japan

Mechanism of Action

Pirenoxine acts to prevent and inhibit the denaturation of lens proteins, a process that leads to lens opacity and the development of cataracts.
By blocking the binding of quinone compounds to lens proteins, pirenoxine helps slow down the progression of early-stage senile (age-related) cataracts, maintaining lens transparency and visual clarity.

Indications

• Early or initial stages of senile (age-related) cataracts
• Prevention of further lens opacity or visual deterioration

Dosage and Administration

• Shake the bottle well before each use (the product is a suspension).
• Instill 1–2 drops into the affected eye(s) 3–5 times daily, or as directed by an ophthalmologist.
• Wash hands before use. Tilt the head back, gently pull down the lower eyelid, and apply the drops without touching the eye or eyelashes.
• If using multiple ophthalmic medications, wait at least 5 minutes between applications.

Contraindications and Precautions

• Hypersensitivity to pirenoxine or any of the formulation components.
• Use under medical supervision only.
• Remove soft contact lenses before application and wait at least 5–10 minutes before reinsertion.
• Use with caution during pregnancy or lactation — only if clearly needed and prescribed by a physician.
• Avoid contamination by not touching the dropper tip to any surface, including the eye.

Possible Side Effects

Most reactions are mild and transient:

• Eye irritation or redness
• Temporary blurred vision
• Mild burning or stinging sensation after instillation

Rarely:

• Blepharitis (eyelid inflammation)
• Contact dermatitis
• Superficial punctate keratitis

If symptoms persist or worsen, discontinue use and consult an ophthalmologist.

Storage Conditions

• Store in a cool, dry place away from direct sunlight.
• Keep tightly closed when not in use.
• Check the expiration date regularly.
• Do not use the product if the suspension changes color or appears contaminated.

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