Prefolic 50 mg/3 ml

Prefolic 50 mg/3 ml is a pharmaceutical product containing Calcium L-methylfolate (N⁵-methyltetrahydrofolate di calcio) — the active, bioavailable form of folic acid. The medication comes as powder and solvent for injectable solution, intended for intramuscular or intravenous administration.

Manufacturer: Zambon
Packaging: 6 vials of powder (50 mg) + 6 solvent ampoules (3 ml)

Indications

Prefolic is used to treat conditions associated with folate deficiency, including:

• severe folic acid deficiency
• megaloblastic anemia
• increased folate requirements (pregnancy, preconception therapy – under medical supervision)
• malabsorption disorders
• therapies requiring elevated levels of active folates

Pharmacological Action

L-methylfolate is the active form of folic acid that does not require metabolic conversion in the liver. It supports:

• normal blood formation
• DNA and RNA synthesis
• proper neurological function
• lowering homocysteine levels
• healthy fetal development (when prescribed by a specialist)

Dosage and Administration

Dosage is determined by a healthcare professional.
The solution is prepared by mixing one vial of powder (50 mg) with the included solvent (3 ml).
Administration routes:

• intramuscular, or
• intravenous

Contraindications

• hypersensitivity to ingredients
• some forms of pernicious anemia (vitamin B12 deficiency must be excluded)
• caution during pregnancy or breastfeeding (medical supervision required)

Side Effects

Possible side effects include:

• allergic reactions
• local injection-site reactions
• very rare gastrointestinal or neurological effects

Storage

Store in a dry, dark place at temperatures up to 25°C. Keep out of reach of children.

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