Pylera 120 capsules

140 mg + 125 mg + 125 mg

Description

Pylera is a medicine used in adults to treat stomach ulcers caused by the bacteria Helicobacter pylori (H. pylori). The drug has the form of solid capsules, which contain 3 active substances. Two of them - tertacycline and metronidazole -are antibiotics, the antibacterial effect of which is facilitated by potassium citrate and bismuth.

Composition

The active ingredients of the drug are: potassium citrate and bismuth (Bismuthi kalii subcitras), metronidazol (Metronidazolum) and tetracycline hydrochloride (Tetracyclini hydrochloridum).

1 solid capsule contains 140 mg of potassium bismuth basic citrate (equivalent to 40 mg of bismuth oxide), 125 mg of metronidazole and 125 mg of tetracycline hydrochloride.

Auxiliary substances: magnesium stearate (E572), lactose monohydrate, talc (E553b), titanium dioxide (E171), gelatin and printing ink containing shellac, propylene glycol and iron oxide red (E 172).

Pylera contains lactose and sodium.

Dosage

This medicine should always be used exactly as described in the patient's booklet or in accordance with the recommendations of a doctor or pharmacist. If in doubt, contact your doctor or pharmacist.

Pyrel should be used together with a proton pump inhibitor, for example, omeprazole.

The dosage of the drug is determined by the doctor. For adults, 3 capsules are usually used 4 times a day - after breakfast, lunch, dinner and before bedtime (after a snack). After breakfast and dinner, it is also recommended to take 20 mg of omeprazole together with Pirel.

It is very important to use 10-day therapy.

Solid capsules should be swallowed whole while sitting, washed down with a full glass (250 ml) of water, which prevents irritation of the throat. Do not go to bed immediately after using the drug.

Action

Pylera is one of the medicines used in four-drug therapy. Potassium bismuth citrate, metronidazole and tetracycline hydrochloride have antibacterial effects. In this combination of active substances, bismuth supports the action of antibiotics (metronidazole and tetracycline). The fourth component of four-stroke therapy is Omeprazole, which belongs to proton pump inhibitors (PPIs). The effect of this group of drugs is to reduce the amount of acid released in the stomach. The combination of active substances contained in the preparation of Pirel and omeprazole treats Helicobacter pylori infection, as well as relieves inflammation of the gastric mucosa.

Indications

Pylera is used in adults to treat infections with the bacterium Helicobacter pylori that have been sick or have stomach ulcers.

Contraindications

When not to use a Pylera:

if the patient is pregnant or breastfeeding,

in patients under the age of 12,

if the patient has disorders related to the kidneys, liver,

if the patient has an allergy (hypersensitivity) to potassium bismuth citrate, metronidazole or other nitroimidazole derivatives, tetracycline or any other component of the drug.

Side effects

Like any medicine, this medicine can cause side effects, although not everyone has them.

If you experience symptoms of an allergic reaction described in the leaflet attached to the package, stop taking the drug and contact your doctor or contact the nearest hospital.

A very rare side effect after using the drug is encephalopathy, that is, a brain disease. It manifests itself in different ways, but can be characterized by fever, neck stiffness, headache, seeing or hearing non-existent things. There may also be problems with arm and leg movement, speech, or a feeling of confusion. If you experience this type of symptoms, you should consult your doctor.

Pylera can also cause other side effects with varying frequency.

Very common side effects: changes in the color and consistency of the stool (even black coloration may occur), diarrhea, nausea, an unusual or metallic taste in the mouth.

Common side effects: abdominal pain, headache, constipation, dry mouth, vomiting, wind/bloating, feeling weak, lack of energy and fatigue, general malaise, vaginal infections-symptoms including itching and irritation in the genital area, burning or yellowish/white vaginal discharge, blood tests may indicate increased activity of liver enzymes (transaminases), dark urine, loss or decrease in appetite, dizziness, drowsiness, skin problems such as redness (rash).

Unusual side effects: allergic reaction to the drug (symptoms include swelling of the face, mouth, tongue or esophagus, which may make it difficult to swallow or breathe; itchy bulging rash or urticaria, hiccups or belching, open mouth ulcers/mouth ulcers, discoloration of the tongue (dark tongue), swelling of the tongue; * pain in the mouth breast, yeast infection (candidiasis), which may include the oral cavity (symptoms-white spots inside the mouth) or genitals (symptoms -severe itching, burning, irritation), numbness, tingling, tremor, feelings of anxiety, depression or difficulty sleeping; • memory disorders.

The frequency is unknown: serious disease with blisters on the skin, in the mouth, around the eyes and genitals (Stevens-Johnson syndrome), serious disease with blisters on the skin (Lyell syndrome, toxic epidermal necrosis), flu symptoms, rash on the face, spreading throughout the body with high fever, increased number of certain types leukocytes (eosinophilia) and enlarged lymph nodes (DRESS), blisters (blisters on the skin) and peeling of the skin, aseptic meningitis: a set of symptoms including fever, nausea, vomiting, headache, neck rigidity and extreme sensitivity to light. This can be caused by inflammation of the membranes covering the brain and spinal cord (meningitis), nerve damage (peripheral neuropathy), pseudomembranous colitis.

Warnings and precautions

Cases of severe hepatotoxicity, acute liver failure and even death have been reported in people with very sudden Cockayne syndrome after the use of systemic metronidazole.

Tell your doctor immediately and stop taking metronidazole if you experience: abdominal pain, lack of traction, nausea, vomiting, fever, malaise, fatigue, jaundice, dark urine, dark stools or itching.

Peeler may affect the results of laboratory tests. Care should be taken with X-ray X-rays, as the drug may affect the result.

During therapy with the drug, sun exposure and tanning in a solarium should be avoided, since Peeler capsules enhance the effect of sunny rooms.

It is recommended to take the drug after meals, but when using Pylera capsules, dairy products or products with added calcium should not be consumed. Alcohol should not be consumed during the use of Pilera and within 24 hours after the end of therapy.

The drug contains lactose and potassium, so if you have an intolerance to certain sugars, you should consult your doctor before using Peeler capsules. Pilera contains 96 mg of potassium in one dose (3 capsules, each containing 32 mg of potassium), which should be taken into account in patients with reduced renal function and in patients who control the potassium content in the diet.

Use of other medicines

Tell your doctor or pharmacist about all the medications you are currently or recently taking, as well as the medications you plan to take, including those that are available without a prescription.

Pylera can interact with:

Lithium,

Anticoagulant drugs (e.g. Warfarin),

Phenytoin and phenobarbital,

Metoksyfluranem,

Other antibiotics, especially with penicillins,

Food additives that contain: iron, zinc, sodium hydroxide,

With other drugs containing bismuth-prolonged use may affect the nervous system,

Busulfan and fluorouracil,

Cyclosporine,

Disulfiramem,

Ranitidine,

Retinoids,

Atovaquon,

Antacids that contain: aluminum, calcium, magnesium.

Pregnancy and breast-feeding

If you are pregnant or breastfeeding, she assumes that she may be pregnant, or when she plans to have a baby, she should consult a doctor or pharmacist before using this medicine.

Do not use the drug during pregnancy and lactation.

The use of the drug in children and adolescents

The peeler cannot be used in children under 12 years of age. The use of the drug is not recommended for adolescents aged 12 to 18 years.

Driving and operating cars

Do not drive vehicles or operate machinery if you experience dizziness, drowsiness, seizures, or a feeling of temporarily blurred or double vision.

APTALIS PHARMA SAS