Sprycel 100 mg​ (Dasatinib) 30 tab

Sprycel 100 mg (Dasatinib)

Sprycel 100 mg (active ingredient: Dasatinib) is a targeted anticancer medicine developed by Bristol-Myers Squibb.

It belongs to the class of tyrosine kinase inhibitors (TKIs) and is used to treat specific types of leukemia, including Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) and acute lymphoblastic leukemia (Ph+ ALL).

Sprycel acts by blocking the abnormal BCR-ABL kinase, a protein responsible for uncontrolled cancer cell growth, thereby stopping or slowing down the progression of leukemia.

Indications

Sprycel is indicated for:

• Adults and children with Ph+ chronic myeloid leukemia (CML) in chronic, accelerated, or blast crisis phases.
• Adults with Ph+ acute lymphoblastic leukemia (ALL) that is resistant or intolerant to prior therapy (e.g., imatinib).
• First-line treatment for newly diagnosed Ph+ CML in adults.

Dosage and Administration

• Typical adult dose: 100 mg once daily (for chronic phase CML).
• For advanced phases or Ph+ ALL — dosage may be increased to 140 mg daily as prescribed by an oncologist.
• Tablets should be swallowed whole with water, with or without food.
• Treatment must be supervised by a hematologist or oncologist.

Mechanism of Action

Dasatinib inhibits multiple tyrosine kinases involved in cancer cell growth and survival — primarily BCR-ABL and SRC-family kinases.
This dual inhibition helps control abnormal cell proliferation and supports remission in patients with resistant forms of leukemia.

Possible Side Effects

Common:

• Fatigue, nausea, diarrhea, headache
• Low blood cell counts (neutropenia, anemia, thrombocytopenia)
• Fluid retention or mild edema

Serious (require medical supervision):

• Pulmonary arterial hypertension (rare)
• Bleeding or infections due to bone marrow suppression

Precautions

• Not recommended during pregnancy or breastfeeding.
• Regular blood monitoring is required.
• Avoid using strong CYP3A4 inhibitors or inducers.
• Grapefruit juice should be avoided during therapy.

Storage

Store below 30°C, in a dry place away from direct sunlight.
Keep out of reach of children.

Manufacturer

Bristol-Myers Squibb Pharma, France / Ireland
Distributed under EU Good Manufacturing Practice (GMP) standards.