Tamoxifen 20 mg Sandoz 100 tab.
21,00 €
Breast cancer
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Tamoxifen 20 mg Sandoz 100 tab.
Product Details
Tamoxifen 20 mg Sandoz 100 tab. It is a drug used in the treatment of breast cancer. It belongs to a group of drugs called selective estrogen receptor modulators (SERMS). This drug blocks the action of estrogen in breast tissues, which helps slow down the growth and spread of cancer cells. Tamoxifen 20 mg Sandoz is available in tablet form and should be taken as prescribed by a doctor. It is an effective and widely used drug for the treatment of breast cancer, and has been proven to help improve patient survival rates.
Active substance:
Tamoxifen
Indications for use
Estrogen-dependent breast cancer in women (especially in menopause) and breast cancer in men after castration.
The drug can be used to treat ovarian cancer, endometrial cancer, kidney cancer, melanoma, soft tissue sarcomas in the presence of estrogen receptors in the tumor, as well as to treat prostate cancer with resistance to other drugs.
Contraindications
- Hypersensitivity to tamoxifen and/or any other ingredient of the drug,
- Thrombophlebitis,
- Pregnancy and breast-feeding,
- Use with caution in the treatment of patients with kidney pathology, diabetes mellitus, ophthalmic diseases, thromboembolic disorders in the anamnesis, hyperlipidemia, leukopenia, thrombocytopenia, hypercalydiemia.
Method of administration and dosage
The dosage regimen is usually set individually depending on the indications. The daily dose is 20-40 mg.
As a standard dose, it is recommended to take 20 mg of tamoxifen orally daily for a long time until signs of disease progression appear.
Tablets should be taken without chewing, washed down with a small amount of liquid, with meals in one dose in the morning, or dividing the required dose into two doses, morning and evening.
Side effect
In the treatment of tamoxifen, the most common adverse reactions associated with its antiestrogenic effect are manifested in the form of paroxysmal sensations of heat (hot flashes), vaginal bleeding or discharge, itching in the genital area, alopecia, pain in the area of the lesion and in the bones.
Interaction with other medicinal products
With the simultaneous administration of tamoxifen and cytostatics, the risk of thrombosis increases.
There are reports of tamoxifen potentiating the anticoagulation effect of coumarin-type drugs (for example, warfarin).
Medications that reduce renal calcium excretion, such as thiazide-type diuretics
, may increase the risk of hypercalcemia.
There are two reports of cases where the combined use of tamoxifen and tegafur caused active chronic hepatitis and cirrhosis of the liver.
The simultaneous use of tamoxifen with other hormonal drugs (especially estrogen-containing contraceptives) leads to a weakening of the specific effect of both drugs.
Application features
Women receiving tamoxifen should undergo regular gynecological examination. If there is bleeding from the vagina or vaginal bleeding, the drug should be discontinued.
In patients with bone metastases, the concentration of calcium in the blood serum should be periodically determined during the initial period of treatment. In case of severe violations, tamoxifen should be temporarily discontinued.
Tamoxifen can cause ovulation, which increases the risk of pregnancy, and therefore women who are sexually active during (and for about 2 months after) tamoxifen treatment are recommended to take a mechanical or non-hormonal contraceptive.
Manufacturer SANDOZ (Slovenia)
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