Tofacitinib 5 mg 60 Tab

Tofacitinib 5 mg 60 tab. It is a medication used to treat adults with rheumatoid arthritis.

Each tablet contains 5 mg of tofacitinib, an active ingredient that helps reduce inflammation and pain associated with this disease. This drug suppresses the action of certain enzymes that cause inflammation in the body, and helps those who suffer from rheumatoid arthritis. It is taken orally, usually once or twice a day, as directed by a doctor. Before taking this drug, it is important to read the instructions that come with the drug and consult with your doctor to make sure that this is the right treatment option for you.

Indications for use

Rheumatoid arthritis: Tofacitinib is indicated for the treatment of adult patients with moderate to severe active rheumatoid arthritis (a chronic disease that causes mainly pain and swelling of the joints) with an inadequate response to one or more basic anti-inflammatory drugs. Psoriatic arthritis: Tofacitinib is indicated for the treatment of adult patients with active psoriatic arthritis (an inflammatory joint disease often accompanied by psoriasis) with an inadequate response to one or more basic anti-inflammatory drugs. Ankylosing spondylitis: Tofacitinib is indicated for the treatment of adult patients with active ankylosing spondylitis (an inflammatory disease in which the spine is predominantly affected) with an inadequate response to traditional therapy. Plaque psoriasis: Tofacitinib is indicated for the treatment of adult patients with moderate to severe chronic plaque psoriasis when systemic therapy or phototherapy is indicated. Ulcerative colitis: Tofacitinib is indicated for induction and maintenance therapy of adult patients with moderate or severe active ulcerative colitis (chronic inflammatory disease of the mucous membrane of the colon) with insufficient response, loss of response or intolerance to glucocorticosteroids, azathioprine, 6-mercaptopurine or tumor necrosis factor inhibitors. Polyarticular juvenile idiopathic arthritis: Tofacitinib is indicated for the treatment of active polyarticular juvenile idiopathic arthritis in patients aged 2 years and older.

Method of application and dosage

Always take the drug in full accordance with the recommendations of your doctor. If in doubt, consult your doctor. Rheumatoid arthritis: the recommended dose is 5 mg twice a day. The attending physician may change the dose of the drug depending on the response to therapy. Psoriatic arthritis: the recommended dose is 5 mg twice a day. Ankylosing spondylitis: the recommended dose is 5 mg twice a day. Plaque psoriasis: the recommended dose is 10 mg twice a day. Ulcerative colitis: the recommended dose is 10 mg twice a day for 8 weeks, then 5 mg or 10 mg twice a day, depending on the response to therapy. The attending physician may increase the duration of the initial dose of 10 mg twice a day if you have previously taken biological drugs for the treatment of ulcerative colitis (for example, drugs that inhibit the activity of necrosis factor, tumors), which did not help you. The attending physician may decide to discontinue Tofacitinib if tofacitinib does not have a therapeutic effect within 16 weeks of use. Your doctor may increase the dose to 10 mg twice a day if you have a decreased response to tofacitinib therapy at a dose of 5 mg twice a day. When using Tofacitinib, according to all indications, the attending physician may change the dose of the drug, suspend treatment with Tofacitinib for a while, or cancel therapy if you have too low a number of lymphocytes or neutrophils, or low hemoglobin levels according to the results of a blood test. Your doctor may also reduce the dose of Tofacitinib if you have impaired liver or kidney function, or if you require the use of other medications. Use in children and adolescents: Tofacitinib is used in children over 2 years of age only for the treatment of polyarticular juvenile idiopathic arthritis. The recommended dose is 5 mg twice a day for patients with a body weight of 40 kg or more. Route and (or) method of administration: the drug Tofacitinib is taken orally. You can take the drug Tofacitinib regardless of the meal. Duration of therapy: the duration of therapy is determined by the attending physician. You should not stop taking Tofacitinib without discussing it with your doctor. If you forgot to take the drug Tofacitinib: do not take a double dose to compensate for the missed dose. Take the next dose at the usual time and continue taking the drug as usual. If you have questions about the use of the drug, contact your doctor.

Contraindications

Allergy to tofacitinib or any other components of the drug; severe liver dysfunction; if you are infected with hepatitis B and/or C viruses; if you have recently received and plan to receive a live vaccine during therapy; if you are currently taking biological drugs such as tumor necrosis factor inhibitors, interleukin antagonists (IL-1R IL-6R), monoclonal anti-CD20 antibodies, IL-17 antagonists, IL-12/IL-23 antagonists, antiintegrins, selective co-stimulating modulators, as well as powerful immunosuppressants such as azathioprine, cyclosporine and tacrolimus; if you have a severe infection, an active infection, including local severe infectious diseases; lactase deficiency, lactose intolerance, or impaired absorption of sugars in the gastrointestinal tract. Do not take Tofacitinib at a dose of 10 mg twice a day: if you are currently taking combined hormonal contraceptives or hormone replacement therapy; if you have been diagnosed with heart failure; if you have had venous thromboembolism in the past, namely deep vein thromboembolism or pulmonary embolism; if you have a hereditary blood clotting disorder; if you have been diagnosed with a malignant neoplasm; if you are scheduled for significant surgery during therapy. If you still have any doubts, contact your doctor before taking Tofacitinib.

Pharmacological action

The drug Tofacitinib contains the active substance tofacitinib, which belongs to the group of immunosuppressants (agents that inhibit immunity), inhibitors of the Janus kinase family (enzymes involved in carrying signals of some small protein molecules into the cell - hormones and cytokines). Tofacitinib's mode of action: Tofacitinib blocks the action of enzymes - intracellular janus kinases, which are involved in the activation of cytokines involved in the development of immune and inflammatory responses. Tofacitinib, by blocking their action, weakens cytokine signaling, which leads to a change in immune and inflammatory responses. If you have any questions about how Tofacitinib works, or why you were prescribed this drug, contact your doctor. If there is no improvement or you feel worse, you should consult a doctor.

Manufacturer of Sakura (India)