Metoject 15 мг / 0,30 мл (метотрексат)

Metoject 15 mg / 0.30 ml is a prefilled syringe containing methotrexate, widely used in rheumatology, dermatology, and oncology to manage autoimmune and inflammatory diseases.

It offers precise dosing, improved bioavailability, and greater convenience compared to oral methotrexate.

Состав и форма

• Active ingredient: Methotrexate
• Strength: 15 mg / 0.30 ml
• Form: Solution for injection
• Type: Prefilled syringe
• Route: Subcutaneous

Механизм действия

Methotrexate:

• suppresses immune system overactivity
• reduces inflammation
• inhibits DNA synthesis in rapidly dividing cells
• blocks dihydrofolate reductase

Показания

• Ревматоидный артрит
• Psoriasis and psoriatic arthritis
• Juvenile idiopathic arthritis
• Autoimmune diseases
• Selected oncology indications

Important Note

❗ Must be used once weekly only, not daily.

Преимущества

• Ready-to-use syringe
• Accurate dosing
• Better absorption vs tablets
• Reduced gastrointestinal side effects
• Suitable for self-administration

Противопоказания

• Pregnancy and breastfeeding
• Severe liver/kidney disease
• Immunodeficiency
• Active infections
• Alcohol abuse

Побочные эффекты

• Nausea, vomiting
• Fatigue
• Low white blood cell count
• Повышенный уровень печеночных ферментов
• Mouth ulcers
• Rare: severe infections

Recommendations

• Regular blood monitoring required
• Often combined with folic acid or folinic acid
• Avoid alcohol
• Follow prescribed schedule strictly

Metoject vs Methotrexate Tablets

Feature	Metoject (Injection)	Methotrexate Tablets
Form	Pre-filled syringe (subcutaneous)	Oral tablets
Bioavailability	High and consistent	May decrease at higher doses
Absorption	Independent of GI tract	Affected by digestion
Frequency	Once weekly	Once weekly
Ease of use	Requires injection technique	Easy oral intake
GI side effects	Minimal	Common (nausea, irritation)
Dose accuracy	Very precise	Can vary
Best for	Poor tolerance to tablets	Mild cases

When is Metoject preferred?

• Gastrointestinal intolerance to oral methotrexate
• Inadequate response to tablets
• Need for higher bioavailability
• More predictable therapeutic effect

When are tablets suitable?

• Early-stage treatment
• Good tolerance
• Convenience and non-invasive use

Часто задаваемые вопросы

What is Metoject?

An injectable methotrexate formulation.

How often is it used?

Once per week.

Is it better than tablets?

Often yes — better absorption and tolerance.

Do I need folic acid?

Yes, usually recommended.

Can I self-inject?

Yes, after proper training.

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