Actovegin Injectable Solution 40 mg/ml (Takeda)

Actovegin — Injectable Solution 40 mg/ml, Takeda

Actovegin by Takeda is a deproteinized hemoderivative of calf blood - a purified biological extract without protein components. It is one of the most widely used injectable preparations in neurological and metabolic practice across Europe and Russia.

Available variants (select above):

• 2 ml × 25 ampoules - 80 mg per ampoule; standard course format for daily IM/IV protocols
• 5 ml × 5 ampoules - 200 mg per ampoule; convenient for medium-dose regimens
• 10 ml × 5 ampoules - 400 mg per ampoule; high-dose format for IV infusion protocols

Composition

• Active: Actovegin concentrate (deproteinized hemoderivative of calf blood) - 40 mg/ml
• Excipients: sodium chloride, water for injection

Why Actovegin is used

• Cerebrovascular disorders and cognitive decline (as part of combination therapy)
• Ischemic stroke recovery and traumatic brain injury rehabilitation
• Peripheral vascular disorders (diabetic polyneuropathy, arterial and venous insufficiency)
• Wound healing and trophic disorders (radiation damage, ulcers, burns)

Mechanism

The hemoderivative increases cellular glucose uptake and utilization independent of insulin, improves ATP metabolism and oxygen transport at the tissue level. In simple terms: it helps cells survive and recover under ischemia and energy deficit.

Administration

• Routes: intramuscular, intravenous (slow injection or infusion), intra-arterial - as determined by the physician
• Typical oral-course alternative exists (tablets), but this card covers the injectable solution
• Dose and duration are set by the physician; common IV protocol starts at 10-20 ml/day diluted in 200-300 ml saline
• Allergy history check before first injection is standard practice

Product features

• Original Takeda product
• Sterile solution, ready to use (no reconstitution needed)
• Suitable for both neurological and wound-healing protocols
• Three pack formats covering adult course, pediatric dosing and IV infusion

Contraindications

Hypersensitivity to Actovegin or its components. Pregnancy and breastfeeding - only under medical supervision. Not for children without prescription.

FAQ

Which pack should I choose?

For classic 10-day IM courses the 2 ml × 25 pack is the common format. For IV infusion protocols the 10 ml × 5 pack covers the standard start. The 5 ml × 5 pack suits mid-dose regimens. Your physician's prescription determines the choice.

Does Actovegin need reconstitution?

No. Unlike lyophilized products (e.g., Cortexin), Actovegin injectable solution is ready to use.

Actovegin vs Cortexin - what is the difference?

Both are cerebral-support injectables but different classes: Actovegin is a blood-derived metabolic enhancer (glucose/oxygen utilization), Cortexin is a peptide nootropic from cortical tissue. In practice they are often used in complementary treatment schemes.

Why is Actovegin not sold in some countries?

Actovegin is registered and widely used in Europe (original Takeda), Russia, CIS and Asia. It is not FDA-approved in the USA - that is a regulatory difference, not a quality one.

Can it be stored after opening an ampoule?

No. Use the entire ampoule contents immediately after opening; ampoules are single-use. Store the unopened box below 25 C, protected from light.

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