Olaparib​​ (Bracanat​) 150 mg​ 30 tab

Olaparib (Bracanat) 150 mg

Manufacturer: Natco Pharma Ltd. (India)
Pack Size: 30 tablets

Description

Bracanat 150 mg contains Olaparib, a targeted cancer therapy from the class of PARP inhibitors (Poly ADP-ribose polymerase inhibitors).
It works by blocking the PARP enzyme, which helps repair damaged DNA in cancer cells. In patients with BRCA1 or BRCA2 mutations, this blockage prevents the repair of cancer cell DNA, causing the cells to die.
Olaparib is a proven and effective treatment for several BRCA-mutated cancers, helping to delay disease progression and improve survival rates.

Active Ingredient

Olaparib – 150 mg per tablet

Indications

Bracanat is prescribed for the treatment and maintenance therapy of:

• Ovarian, fallopian tube, or primary peritoneal cancer (with BRCA mutation)
• Breast cancer (HER2-negative, BRCA-positive)
• Prostate cancer (with homologous recombination repair gene mutations)
• Pancreatic cancer (in patients with BRCA mutations)

Mechanism of Action

Olaparib selectively inhibits the PARP enzyme, preventing the repair of single-strand DNA breaks in tumor cells.
This leads to the accumulation of DNA damage and cancer cell death, while sparing most normal cells.

Dosage & Administration

• Recommended dose: 300 mg twice daily (two 150 mg tablets every 12 hours)
• Tablets should be swallowed whole with water, with or without food
• Dose adjustments may be required based on tolerance or kidney/liver function
• Treatment should be supervised by an oncologist

Side Effects

Common side effects include:

• Fatigue, weakness
• Nausea, vomiting, loss of appetite
• Anemia, low blood cell counts
• Diarrhea or stomach discomfort
• Headache, taste changes
• Rash or mild itching

Serious but rare effects:

• Myelodysplastic syndrome (MDS) / acute myeloid leukemia (AML)
• Pneumonitis (lung inflammation)

Precautions

• Not recommended during pregnancy or breastfeeding
• Use effective contraception during and after treatment
• Regular blood tests are required to monitor blood counts and organ function
• Avoid use in patients with severe liver or kidney disease