Angeliq 1 mg/2 mg (Estradiol + Drospirenone) — Product Description

Angeliq is the original Bayer Schering Pharma preparation for hormone replacement therapy (HRT). Each film-coated tablet contains 1 mg estradiol (as estradiol hemihydrate) and 2 mg drospirenone — an estrogen-progestogen combination designed for continuous daily use in postmenopausal women.

• Active ingredients: Estradiol 1 mg (as estradiol hemihydrate) + Drospirenone 2 mg per tablet
• Pack: 28 film-coated tablets (blisters with days of the week)
• Manufacturer: Bayer Schering Pharma (Germany)

Drospirenone is a unique progestogen: it is structurally similar to spironolactone, so unlike classic progestins it also has mild antimineralocorticoid activity. In practical terms: it counteracts estrogen-related fluid retention rather than adding to it — many women on Angeliq report less bloating and water retention compared to other HRT regimens.

At the same time, drospirenone provides reliable endometrial protection — the reason every estrogen-based HRT needs a progestogen component in women with an intact uterus.

Angeliq is prescribed by gynecologists for:

• hormone replacement therapy for estrogen deficiency symptoms in postmenopausal women more than 1 year after menopause;
• prevention of postmenopausal osteoporosis in women at high fracture risk who cannot take other osteoporosis-prevention medicines.

HRT should be initiated only for symptoms that adversely affect quality of life, at the lowest effective dose, with annual benefit-risk review — this is the official European guidance and our position as well.

• One tablet daily, swallowed whole with liquid, at the same time each day;
• Continuous regimen: no break between packs — finish one blister, start the next;
• Can be started any day (if not taking other HRT) or the day after finishing a cyclic regimen;
• Missed tablet: take as soon as possible; if more than 24 hours passed, skip (do not double);
• Effect on vasomotor symptoms typically develops within the first weeks.

• Original Bayer product;
• Drospirenone — antimineralocorticoid progestogen (less fluid retention);
• Continuous combined regimen — predictable cycle;
• Blister with week-day markings — easy adherence control;
• Suitable for long-term therapy with annual medical review.

Commonly reported adverse reactions:

• breast tension/pain;
• headache;
• nausea;
• irregular spotting in early months (typically decreases);
• rare: thromboembolic events — risk factors are assessed by the physician before starting.

Medical attention should be sought for unusual leg pain/swelling, chest pain, severe headache or heavy unexpected bleeding.

• Undiagnosed genital bleeding;
• Known or suspected breast cancer or estrogen-dependent tumors;
• Current or previous venous thromboembolism; active arterial thromboembolic disease;
• Acute liver disease; thrombophilic disorders; severe renal insufficiency; porphyria;
• Pregnancy and breastfeeding.

A full health assessment (blood pressure, breast, thrombosis risk factors) is mandatory before starting any HRT — this is standard gynecological practice.

FAQ — Frequently Asked Questions

What is the difference between Angeliq and Angelique/Estradiol-only HRT?

Angeliq is a continuous combined HRT: estradiol + drospirenone in every tablet, taken without breaks. Estrogen-only therapy is for women after hysterectomy. If the uterus is intact, the progestogen component is mandatory to protect the endometrium.

Why drospirenone instead of classic progestins?

Drospirenone has antimineralocorticoid activity — it counteracts fluid retention instead of adding to it. Plus reliable endometrial protection. This combination is the distinguishing feature of Angeliq among combined HRTs.

Do I take breaks between packs?

No — Angeliq is continuous: finish one blister, start the next the next day. The week-day markings on the blister help maintain adherence.

When will hot flushes improve?

Vasomotor symptoms typically improve within the first weeks of therapy. Full stabilization takes 1–2 months. If symptoms persist, the physician may adjust the dose.

Is medical consultation necessary?

Yes. Angeliq is a prescription medication. Annual benefit-risk review, blood pressure control and periodic gynecological assessment are standard practice for any HRT.

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