Isovorin 5mg (Calcium levofolinate)

Isovorin 5 mg (Calcium levofolinate) - Full Description

Isovorin 5 mg is a pharmaceutical product containing levofolinic acid (calcium levofolinate) — the biologically active form of folic acid. It is widely used in oncology, hematology, and for treating folate deficiency.

Unlike regular folic acid, levofolinate does not require metabolic activation, making it more effective in patients with impaired folate metabolism.

Composition and Form

• Active ingredient: Calcium levofolinate (levofolinic acid)
• Strength: 5 mg
• Form: Oral tablets
• Pack size: 30 tablets
• Manufacturer: Pfizer

Mechanism of Action

Levofolinic acid:

• supports DNA and RNA synthesis
• promotes cell division and repair
• restores folate metabolism
• reduces toxicity of antifolate drugs (e.g., methotrexate)

It acts immediately without requiring liver conversion.

Indications

• Methotrexate toxicity rescue
• Folate deficiency
• Megaloblastic anemia
• Combination chemotherapy (e.g., with 5-fluorouracil)
• Folate metabolism disorders
• Support in neurological conditions

Use in Autism

Levofolinic acid is being studied for autism spectrum disorders, especially in patients with:

• cerebral folate deficiency
• folate receptor autoantibodies

Potential benefits include:

• improved speech
• better cognition
• enhanced social interaction

⚠️ Should only be used under medical supervision.

Contraindications

• Hypersensitivity
• Excess folate levels
• Use with caution in epilepsy

Side Effects

• Allergic reactions
• Insomnia
• Irritability
• Nausea
• Rare: seizures

Key Features

• Active form (no conversion needed)
• High bioavailability
• Rapid onset of action
• Widely used in clinical protocols

FAQ

What is Isovorin?

A medication containing active folinic acid (levofolinate).

How is it different from folic acid?

It is already active and works immediately without conversion.

What is it used for?

Cancer therapy support, anemia, and folate deficiency.

Can it be used for autism?

In selected cases under medical supervision.

How fast does it work?

Usually within days, depending on the condition.

Read the article

Calcium Folinate for autism

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