Metoject 15 mg / 0.30 ml (Methotrexate)

Metoject 15 mg / 0.30 ml is a prefilled syringe containing methotrexate, widely used in rheumatology, dermatology, and oncology to manage autoimmune and inflammatory diseases.

It offers precise dosing, improved bioavailability, and greater convenience compared to oral methotrexate.

Composition and Form

• Active ingredient: Methotrexate
• Strength: 15 mg / 0.30 ml
• Form: Solution for injection
• Type: Prefilled syringe
• Route: Subcutaneous

Mechanism of Action

Methotrexate:

• suppresses immune system overactivity
• reduces inflammation
• inhibits DNA synthesis in rapidly dividing cells
• blocks dihydrofolate reductase

Indications

• Rheumatoid arthritis
• Psoriasis and psoriatic arthritis
• Juvenile idiopathic arthritis
• Autoimmune diseases
• Selected oncology indications

Important Note

❗ Must be used once weekly only, not daily.

Benefits

• Ready-to-use syringe
• Accurate dosing
• Better absorption vs tablets
• Reduced gastrointestinal side effects
• Suitable for self-administration

Contraindications

• Pregnancy and breastfeeding
• Severe liver/kidney disease
• Immunodeficiency
• Active infections
• Alcohol abuse

Side Effects

• Nausea, vomiting
• Fatigue
• Low white blood cell count
• Elevated liver enzymes
• Mouth ulcers
• Rare: severe infections

Recommendations

• Regular blood monitoring required
• Often combined with folic acid or folinic acid
• Avoid alcohol
• Follow prescribed schedule strictly

FAQ

What is Metoject?

An injectable methotrexate formulation.

How often is it used?

Once per week.

Is it better than tablets?

Often yes — better absorption and tolerance.

Do I need folic acid?

Yes, usually recommended.

Can I self-inject?

Yes, after proper training.

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